According to Volvo, the upholstery in the V50's five-passenger interior was inspired by sportswear. The instrument panel's texture is meant to signal technical innovation to the occupant. An Intelligent Driver Information System helps the driver focus on driving by selectively limiting nonessential information. A storage compartment can be accessed from behind either side of the ultra-slim center stack.

The rear seat is a split, folding unit. The front passenger seatback can also be folded. Four upholstery types are available. A navigation system is optional on T5 editions, and a 325-watt stereo with Dolby Pro-Logic II Surround Sound is optional on all V50s.